Tumor Inhibition by Enzalutamide in a Xenograft Model of Ovarian Cancer
نویسندگان
چکیده
منابع مشابه
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer.
One of the key limiting factors in the treatment of advanced stage human epithelial malignancies is the lack of selective molecular targets for antineoplastic therapy. A substantial subset of human ovarian, endometrial, breast, colorectal, and prostatic cancers exhibit increased endogenous fatty acid biosynthesis and overexpress certain enzymes in the pathway. Cell lines derived from these tumo...
متن کاملOvarian Tumor Xenograft in Mice
Elmezzi Graduate School of Molecular Medicine, Manhasset, NY, United States. The Center for 6 Immunology and Inflammation, Feinstein Institute for Medical Research, North Shore-LIJ Health 7 System, Manhasset, NY, United States. Hofstra North Shore-LIJ School of Medicine, Manhasset, NY, 8 United States. Department of Pathology, Massachusetts General Hospital, Boston, MA, United States. 9 Divisio...
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BACKGROUND Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if inhibition of this pathway could inhibit serous ovarian cancer growth. METHODOLOGY We utilized an in vivo pre-clinical model of serous o...
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The HDACi Panobinostat Shows Growth Inhibition Both In Vitro and in a Bioluminescent Orthotopic Surgical Xenograft Model of Ovarian Cancer
BACKGROUND In most epithelial ovarian carcinomas (EOC), epigenetic changes are evident, and overexpression of histone deacetylases (HDACs) represents an important manifestation. In this study, we wanted to evaluate the effects of the novel HDAC inhibitor (HDACi) panobinostat, both alone and in combination with carboplatin, on ovarian cancer cell lines and in a murine bioluminescent orthotopic s...
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ژورنال
عنوان ژورنال: Cancer Investigation
سال: 2016
ISSN: 0735-7907,1532-4192
DOI: 10.1080/07357907.2016.1242598